Squamous cell carcinoma of the anus

The main type of anal cancer is Squamous Cell Carcinoma of the Anus. The anus is a canal that connects the lower part of the large intestine rectum to the outside of the body. It allows the faeces to pass from the large intestine during a bowel movement. Faeces are formed in the longest part of the large intestine colon , stored in the rectum, and pass through the anus. Squamous cell carcinoma of the anus forms from the lining of the anal canal.
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Metastatic Squamous Cell Carcinoma of the Anus: Time for a Shift in the Treatment Paradigm?

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Types of anal cancer | Cancer Research UK

Find information and resources for current and returning patients. Learn about clinical trials at MD Anderson and search our database for open studies. The Lyda Hill Cancer Prevention Center provides cancer risk assessment, screening and diagnostic services. Your gift will help support our mission to end cancer and make a difference in the lives of our patients. Our personalized portal helps you refer your patients and communicate with their MD Anderson care team.
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What Is Anal Cancer?

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Chemoradiotherapy is the standard-of-care treatment of squamous-cell carcinoma of the anus SCCA , and this has not changed in decades.
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Anal cancers are rare tumours; however, the incidence is increasing in both men and women. Changing trends in sexual behaviour, smoking, and infection with the human papillomavirus are thought to be responsible for the increase. The standard systemic treatment of metastatic disease remains cisplatin and 5-fluorouracil, and aside from several non-randomised small phase II trials there has been no real progress over the past two decades. Based on the efficacy of cetuximab in squamous cell carcinomas from other primary sites, there appears to be clinical rationale for evaluation of anti-epidermal growth factor inhibitors in anal squamous cell carcinoma. In order to facilitate research and implement more effective treatment strategies international collaboration in clinical trials incorporating tissue collection for biomarkers is essential.
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